Oligomerization dependent enzyme kinetics and mechanistic characterization of type I protein arginine N-methyltransferases

Protein arginine N-methyltransferases (PRMTs) constitute a family of post-translational modifying enzymes that modulate protein-protein interactions via the addition of methyl groups to arginine residues in protein substrates (1). PRMTs have been demonstrated to homooligomerize via a dimerization ar...

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Bibliographic Details
Main Author: Thomas, Dylan
Language:English
Published: University of British Columbia 2013
Online Access:http://hdl.handle.net/2429/44623