Structural requirements for the elastolytic and collagenolytic activities of cathepsins and the identification of exosite inhibitors
It has become increasingly transparent that substrate recognition and degradation of extracellular matrix proteins such as elastin and collagen by proteases require more than the binding to small areas around the scissile bond of the target protein. Important surface structures on proteases, known a...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/45210 |