Molecular basis of the endopeptidase activity of type A botulinum neurotoxin
Clostridial botulinum neurotoxins (BoNTs) cause neuroparalysis by blocking neurotransmitter release. The toxin's light chain (LC) acts as a Zn2+-endopeptidase. Type A botulinum nuerotoxin light chain (BoNT/A LC) was expressed in E. coli to high yield level. The recombinant BoNT/A LC, which reta...
| Main Author: | |
|---|---|
| Language: | ENG |
| Published: |
ScholarWorks@UMass Amherst
2000
|
| Subjects: | |
| Online Access: | https://scholarworks.umass.edu/dissertations/AAI9978520 |