Notch 1 mediated inhibition of Nur77-induced apoptosis: implications for T-cell leukemia
It is widely accepted that activating mutations of genes encoding the Notch family of transmembrane receptors, specifically Notch1, are associated with oncogenic transformation. Previous data from our lab has shown that an active form of Notch1 (Nic) provides a protective effect against apoptosis in...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2010
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3409650 |