The roles of Notch1 and PKC-Θ in immune mediated bone marrow failure

We sought to evaluate the individual contributions of Notch1 and PKC-Theta to disease progression in a mouse model of immune-mediated bone marrow failure and to define a mechanism for their potential cellular cooperation. We transferred parental bulk splenocytes into F1-hybrid recipients to induce a...

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Bibliographic Details
Main Author: Roderick, Justine E
Language:ENG
Published: ScholarWorks@UMass Amherst 2011
Subjects:
Online Access:https://scholarworks.umass.edu/dissertations/AAI3465077