Synthesis and reactivity of various isomers of 7-aza-1-hydroxybenzotriazole (HOAt): Implications for a mechanistic understanding of their use as peptide coupling additives
Previously it was suggested that the reason for the superior performance, in terms of both reactivity and avoidance of loss of configuration in peptide coupling observed for 7-HOAt over HOBt or 4-HOAt was due to the involvement of a cyclic transition state at the stage of the key intermediate, the a...
| Main Author: | |
|---|---|
| Language: | EN |
| Published: |
ScholarWorks@UMass Amherst
1999
|
| Subjects: | |
| Online Access: | https://scholarworks.umass.edu/dissertations/AAI9950165 |