Components of a protein machine: Allosteric domain assembly and a disordered c-terminus enable the chaperone functions of HSP70
Hsp70 molecular chaperones protect proteins from aggregation, assist in their native structure formation, and regulate stress responses in the cell. A mechanistic understanding of Hsp70 function will be necessary to explain its physiological roles and guide the therapeutic modulation of various dise...
| Main Author: | |
|---|---|
| Language: | ENG |
| Published: |
ScholarWorks@UMass Amherst
2011
|
| Subjects: | |
| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3482664 |