Structural Characterization of the Pre-Amyloid Oligomers of β-2-Microglobulin Using Covalent Labeling and Mass Spectrometry
The initial steps involved in the assembly of normally soluble proteins into amyloid fibrils remain unclear, yet over 20 human diseases are associated with proteins that aggregate in this manner. Protein surface modification is a potential means of mapping the interaction sites in early oligomers th...
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ScholarWorks@UMass Amherst
2010
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| Online Access: | https://scholarworks.umass.edu/open_access_dissertations/293 https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1295&context=open_access_dissertations |