Regulation of PDK1 Protein Kinase Activation by Its C-Terminal Pleckstrin Homology Domain
Phosphoinositide-dependent protein kinase-1 (PDK1) plays an integral role in signaling cellular growth and proliferation, one that's dependent on its ability to autophosphorylate Ser-241 in its T-loop. This process appears to have a strict requirement for its C-terminal pleckstrin homology (PH)...
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| Format: | Others |
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Scholarly Repository
2010
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| Online Access: | http://scholarlyrepository.miami.edu/oa_dissertations/381 |