Regulation of PDK1 Protein Kinase Activation by Its C-Terminal Pleckstrin Homology Domain
Phosphoinositide-dependent protein kinase-1 (PDK1) plays an integral role in signaling cellular growth and proliferation, one that's dependent on its ability to autophosphorylate Ser-241 in its T-loop. This process appears to have a strict requirement for its C-terminal pleckstrin homology (PH)...
Main Author: | Al-Ali, Hassan |
---|---|
Format: | Others |
Published: |
Scholarly Repository
2010
|
Subjects: | |
Online Access: | http://scholarlyrepository.miami.edu/oa_dissertations/381 |
Similar Items
-
The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
by: Nam Chu, et al.
Published: (2020-08-01) -
Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily
by: Marc Lenoir, et al.
Published: (2015-10-01) -
Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family
by: Nagarajan Naveenkumar, et al.
Published: (2019-11-01) -
Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase
by: Stevan R. Hubbard
Published: (2018-01-01) -
Substrate specificity of the Bacillus subtilis BY-kinase PtkA is controlled by alternative activators: TkmA and SalA
by: Abderahmane Derouiche, et al.
Published: (2016-09-01)