Dynamics of the voltage-sensor domain in voltage-gated ion channels : Studies on helical content and hydrophobic barriers within voltage-sensor domains

Dynamics of the voltage-sensor domain in voltage-gated ion channels : Studies on helical content and hydrophobic barriers within voltage-sensor domains

Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. T...

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Bibliographic Details
Main Author: Schwaiger, Christine S.
Format: Others
Language:English
Published: KTH, Teoretisk fysik 2011
Subjects:
activation
deactivation
inactivation
voltage-sensor
VSD
Kv1.2- 2.1
F233
hydrophobic barrier
alpha-helix
3(10)-helix
Biological physics
Biologisk fysik
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33818
http://nbn-resolving.de/urn:isbn:978-91-7501-041-0

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33818
http://nbn-resolving.de/urn:isbn:978-91-7501-041-0

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