Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. Furthermore are explained why such...

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Bibliographic Details
Main Author: Bäck, Marcus
Format: Others
Language:English
Published: Linköpings universitet, Organisk Kemi 2006
Subjects:
HCV
NS3 protease
Proline mimic
Cyclopentane-derived scaffold
Linear inhibitors
Macrocyclic inhibitors
Organic synthesis
Organisk syntes
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8395
http://nbn-resolving.de/urn:isbn:91-85523-20-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8395
http://nbn-resolving.de/urn:isbn:91-85523-20-8

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