Evaluation of Rate Constants from Protein-Ligand Interactions with Weak Affinity Chromatography
The paradigm of drug discovery have been to find the strongest possible binder to the target by high-throughput screening (HTS) but high affinity interactions are related to low kinetic off rates and thus result in severe side-effects and non-approved drugs. Lead molecules working in a transient man...
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| Format: | Others |
| Language: | English |
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Linnéuniversitetet, Institutionen för naturvetenskap, NV
2012
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-19974 |