Molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the SCA7 gene resulting in progressive ataxia and retinal dystrophy. SCA7 belongs to a group of neurodegenerative disorders called polyglutamine (polyQ) diseases, that...

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Bibliographic Details
Main Author: Ajayi, Abiodun
Format: Doctoral Thesis
Language:English
Published: Stockholms universitet, Institutionen för neurokemi 2015
Subjects:
NOX
p53
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119846
http://nbn-resolving.de/urn:isbn:978-91-7649-257-4