α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2
The amyloid-β precursor protein (APP) has been widely studied due to its role in Alzheimer´s disease (AD). When APP is sequentially cleaved by β- and γ-secretase, amyloid-β (Aβ) is formed. Aβ is prone to aggregate and is toxic to neurons. However, the main processing pathway for APP involves initial...
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| Format: | Doctoral Thesis |
| Language: | English |
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Stockholms universitet, Institutionen för neurokemi
2013
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-95114 http://nbn-resolving.de/urn:isbn:978-91-7447-732-0 |