Neurogenin 3(+) cells contribute to beta-cell neogenesis and proliferation in injured adult mouse pancreas

Neurogenin 3(+) cells contribute to beta-cell neogenesis and proliferation in injured adult mouse pancreas

We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to beta cells ex vivo. Here we evaluate the role of Ngn3(+) cells in beta cell expansion in situ. PDL not only induced doubling of the beta...

Full description

Bibliographic Details
Main Authors: Van de Casteele, M., Leuckx, G., Baeyens, L., Cai, Y., Yuchi, Y., Coppens, V., De Groef, S., Eriksson, M., Svensson, C., Ahlgren, Ulf, Ahnfelt-Ronne, J., Madsen, O. D., Waisman, A., Dor, Y., Jensen, J. N., Heimberg, H.
Format: Others
Language:English
Published: Umeå universitet, Umeå centrum för molekylär medicin (UCMM) 2013
Subjects:
diabetes
cell differentiation
tissue injury
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70152

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70152

Similar Items