Influence of Genes and Post-translational Modifications in the Pathogenesis of Light Chain Amyloidosis
Amyloid is formed when a normally soluble protein undergoes conformational changes that results in self-aggregation. The pathogenic protein in light chain amyloidosis is an immunoglobulin light chain produced by a plasma cell clone mainly in the bone marrow. The light chain is transported via the ci...
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| Format: | Doctoral Thesis |
| Language: | English |
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Uppsala universitet, Institutionen för genetik och patologi
2009
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100899 http://nbn-resolving.de/urn:isbn:978-91-554-7514-7 |