IRINOTECANTOXICITY RELATED TO GILBERT´S SYNDROME - COMPARISON OF THREE METHODS FOR GENOTYPING OF UGT1A1 (TA)n
Gilbert’s syndrome (GS) occurs in approximately 10% of the European population. The most common cause is homozygosity for UGT1A1*28, which is a TA repeat expansion in the promoter of UGT1A1. It is characterised by intermittent hyperbilirubinemia due to reduced hepatic activity of the enzyme UDP-glu...
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| Format: | Others |
| Language: | English |
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Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi
2009
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107558 |