Tunnels and Grooves : Structure-Function Studies in Two Disparate Enzymes

Tunnels and Grooves : Structure-Function Studies in Two Disparate Enzymes

This thesis describes structural and binding studies in enzymes from two different  organisms: ribonucleotide reductase from Mycobacterium tuberculosis (RNR) and lipase A from Candida antarctica (CalA). RNR is viable as a target for new drugs against the causative agent of tuberculosis. The biologic...

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Bibliographic Details
Main Author: Ericsson, Daniel
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Strukturell molekylärbiologi 2009
Subjects:
Mycobacterium tuberculosis
ribonucleotide reductase
peptide inhibitors
fluorescence polarization
lipase
interfacial activation
hydrolase
X-ray structure
substrate specificity
Structural biology
Strukturbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109697
http://nbn-resolving.de/urn:isbn:978-91-554-7638-0

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109697
http://nbn-resolving.de/urn:isbn:978-91-554-7638-0

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