Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

Cytochrome P450 (CYP) family 4 constitutes monoxygenases responsible for hydroxylation of fatty acids and other lipids. For example, CYP4F3 metabolizes leukotrienes and CYP4F8 prostaglandin H. Importantly, six of the twelve CYP4 enzymes are orphans, i.e., with an unknown biological function. The cat...

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Bibliographic Details
Main Author: Nilsson, Tomas
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2009
Subjects:
epoxyalcohols
fatty acids
hydroperoxides
electrospray ionization
ichthyosis
CYP4
linear ion trap
fragmentation mechanism
Pharmaceutical pharmacology
Farmaceutisk farmakologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109715
http://nbn-resolving.de/urn:isbn:978-91-554-7645-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109715
http://nbn-resolving.de/urn:isbn:978-91-554-7645-8

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