In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. In this thesi...

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Bibliographic Details
Main Author: Matsson, Elin
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2010
Subjects:
Direct thrombin inhibitors
prodrugs
ximelagatran
AZD0837
erythromycin
ketoconazole
drug-drug interactions
hepatobiliary transport
biliary clearance
ATP-binding cassette
ABC transporters
solute carriers
SLC transporters
CYP3A4
Biopharmacy
Biofarmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123419
http://nbn-resolving.de/urn:isbn:978-91-554-7824-7

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123419
http://nbn-resolving.de/urn:isbn:978-91-554-7824-7

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