Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. Disp...

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Bibliographic Details
Main Author: Sjögren, Erik
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2010
Subjects:
Hepatic disposition
pharmacokinetics
mechanistic modelling
drug-drug interactions
enzyme kinetics
Vmax
Km
CLint
carrier-mediated transport
active transport
modelling
in vitro-in vivo extrapolation
physiologically based pharmacokinetic model
optimal experimental design
experimental optimization
data analysis optimization
PHARMACY
FARMACI
Biopharmacy
Biofarmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132571
http://nbn-resolving.de/urn:isbn:978-91-554-7934-3

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132571
http://nbn-resolving.de/urn:isbn:978-91-554-7934-3

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