Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. We colle...

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Bibliographic Details
Main Author: Simonsson, Martin
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Enheten för onkologi 2011
Subjects:
DNA damage response
low-dose hypersensitivity
dose response
normal tissue
epidermis
dermis
keratinocyte
fractionated radiotherapy
DNA double strand break
DSB
foci
gamma-H2AX
53BP1
p21
checkpoint
apoptosis
mitosis
micro-RNA
miR-34a
Oncology
Onkologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134600
http://nbn-resolving.de/urn:isbn:978-91-554-7969-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134600
http://nbn-resolving.de/urn:isbn:978-91-554-7969-5

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