Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. The...

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Bibliographic Details
Main Author: Nordqvist, Anneli
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Avdelningen för organisk farmaceutisk kemi 2011
Subjects:
Tuberculosis
Glutamine synthetase
Imidazo[1
2-a]pyridine analogues
Focused hierarchical design of experiments
DXR
Fosmidomycin analogues
1-Deoxy-D-xylulose-5-phosphate reductoisomerase
Cinnamaldehydes
Oxidative Heck reaction
Pharmaceutical chemistry
Läkemedelskemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155428
http://nbn-resolving.de/urn:isbn:978-91-554-8151-3

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155428
http://nbn-resolving.de/urn:isbn:978-91-554-8151-3

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