Model-Based Optimization of Clinical Trial Designs

Model-Based Optimization of Clinical Trial Designs

General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmac...

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Bibliographic Details
Main Author: Vong, Camille
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2014
Subjects:
nonlinear mixed-effects models
pharmacometrics
likelihood ratio test
NONMEM
power
sample size
study design
proof-of-concept
dose-finding
population optimal design
LOQ
BQL data
neutropenia
docetaxel
myelosuppression
thrombocytopenia
MTD
Bayesian methods
3+3 algorithm
dose escalation study
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233445
http://nbn-resolving.de/urn:isbn:978-91-554-9063-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233445
http://nbn-resolving.de/urn:isbn:978-91-554-9063-8

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