Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine mode...

Full description

Bibliographic Details
Main Author: Jansson, Björn
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2004
Subjects:
Biopharmacy
Administration
intranasal
Nasal mucosa
Central nervous system
Olfactory bulb
Rat
Mouse
Swine
Cattle
Diffusion chambers
culture
In vitro
Biological models
Biological transport
Dextrans
Dopamine
Gels
Polysaccharides
Autoradiography
Fluorescence microscopy
Biofarmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905
http://nbn-resolving.de/urn:isbn:91-554-5834-3

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905
http://nbn-resolving.de/urn:isbn:91-554-5834-3

Similar Items