Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA

Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA

This thesis is based on 9 papers dealing with the synthesis, physicochemical and biochemical properties of two types of chemically modified oligonucleotides which have the potential to down-regulate gene expression: (i) The first set is comprised of antisense oligonucleotides (AONs) conjugated with...

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Bibliographic Details
Main Author: Pradeepkumar, Pushpangadan Indira
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för bioorganisk kemi 2004
Subjects:
Bioorganic chemistry
Antisense oligonucleotides
Dipyridophenazine
Oxetane
RNase H
Gene down-regulation
DNase 1
Charge transport
Bioorganisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4247
http://nbn-resolving.de/urn:isbn:91-554-5957-9

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4247
http://nbn-resolving.de/urn:isbn:91-554-5957-9

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