Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia : Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr
During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown t...
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| Format: | Doctoral Thesis |
| Language: | English |
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Uppsala universitet, Institutionen för farmaceutisk biovetenskap
2000
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-515 http://nbn-resolving.de/urn:isbn:91-554-4828-3 |