Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. A further complicating factor is that paclitaxel when given as Ta...

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Bibliographic Details
Main Author: Henningsson, Anja
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Avdelningen för farmakokinetik och läkemedelsterapi 2005
Subjects:
Pharmacokinetics/Pharmacotherapy
Pharmacokinetics
Pharmacodynamics
Mechanism-based
Modelling
Myelosuppression
Paclitaxel
Cremophor EL
NONMEM
Farmakokinetik/Farmakoterapi
PHARMACY
FARMACI
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5772
http://nbn-resolving.de/urn:isbn:91-554-6232-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5772
http://nbn-resolving.de/urn:isbn:91-554-6232-4

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