Macrolide Antibiotics in Bacterial Protein Synthesis

Macrolide Antibiotics in Bacterial Protein Synthesis

Macrolides are a large group of clinically relevant antibiotics that inhibit protein synthesis by binding to the large ribosomal subunit in the peptide exit tunnel, close to the peptidyl transferase center (PTC). We have shown that the peptide length of the resulting peptidyl-tRNA drop-off products...

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Bibliographic Details
Main Author: Lovmar, Martin
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för cell- och molekylärbiologi 2005
Subjects:
Biochemistry
protein synthesis
macrolides
resistance
initiation of translation
non-competitive inhibitors
kinetics
translation accuracy
proof-reading
Biokemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6009
http://nbn-resolving.de/urn:isbn:91-554-6361-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6009
http://nbn-resolving.de/urn:isbn:91-554-6361-4

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