Pathogenic Mechanisms of the Arctic Alzheimer Mutation

Pathogenic Mechanisms of the Arctic Alzheimer Mutation

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increa...

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Bibliographic Details
Main Author: Sahlin, Charlotte
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap 2007
Subjects:
Neurosciences
Alzheimer's disease
Arctic mutation
Amyloid precursor protein
Amyloid-β
APP processing
Aβ oligomers
Docosahexaenoic acid
Neurovetenskap
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7582
http://nbn-resolving.de/urn:isbn:978-91-554-6806-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7582
http://nbn-resolving.de/urn:isbn:978-91-554-6806-4

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