Protease Activity, Inhibition and Ligand Interaction Analysis : Developments and Applications for Drug Discovery

Protease Activity, Inhibition and Ligand Interaction Analysis : Developments and Applications for Drug Discovery

The present study has focused on characterising protease-ligand interactions in the context of drug discovery. The proteases that have been studied are human matrix metallopeptidase 12 (MMP-12), HIV-protease and Hepatitis C virus (HCV) NS3/NS4A protease. These studies have involved kinetic character...

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Bibliographic Details
Main Author: Gossas, Thomas
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för naturvetenskaplig biokemi 2007
Subjects:
Biochemistry
proteases
kinetics
biosensors
inhibition
calcium
drug discovery
Biokemi
Biochemistry and Molecular Biology
Biokemi och molekylärbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7822
http://nbn-resolving.de/urn:isbn:978-91-554-6866-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7822
http://nbn-resolving.de/urn:isbn:978-91-554-6866-8

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