Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2...

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Bibliographic Details
Main Author: Varghese, Oommen P.
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för biokemi och organisk kemi 2007
Subjects:
Organic chemistry
chemically modified oligonucleotides
azetidine
aza-ENA-T
cyanomethylene locked
free energy of activation
diaxial interactions
chair conformation
stable duplex
human serum
snake venom phosphodiesterase
antisense agents
RNase H
Organisk kemi
Chemistry
Kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8266
http://nbn-resolving.de/urn:isbn:978-91-554-6992-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8266
http://nbn-resolving.de/urn:isbn:978-91-554-6992-4

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