Targeting RNA by the Antisense Approach and a Close Look at RNA Cleavage Reaction

Targeting RNA by the Antisense Approach and a Close Look at RNA Cleavage Reaction

This thesis summarizes the results of studies on two aspects of nucleic acids. Chemically modified antisense oligonucleotides (AONs) have been evaluated with regards to their suitability for mRNA targeting in an antisense approach (Paper I – III). The chemically modified nucleotidic units 2'-O-...

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Bibliographic Details
Main Author: Barman, Jharna
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för biokemi och organisk kemi 2007
Subjects:
Organic chemistry
mRNA targeting
antisense oligonucleotides
target affinity
RNase H
Michaelis-Menten kinetics
exo-nuclease stability
NMR
pH titration
alkaline hydrolysis
Organisk kemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8272
http://nbn-resolving.de/urn:isbn:978-91-554-6995-5

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8272
http://nbn-resolving.de/urn:isbn:978-91-554-6995-5

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