Preclinical Studies of the Melphalan Prodrug J1 for Cancer Therapy
J1 (L-melphalanyl-L-p-fluorophenylalanyl ethyl ester) is a dipeptide derivative of the alkylating agent melphalan with increased cytotoxicity. In this thesis the preclinical pharmacology of J1 has been characterized. Our results show that J1 rapidly enters the cells, where melphalan is released by h...
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| Format: | Doctoral Thesis |
| Language: | English |
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Uppsala universitet, Institutionen för medicinska vetenskaper
2007
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8285 http://nbn-resolving.de/urn:isbn:978-91-554-7005-0 |