The Genetics of Systemic Lupus Erythematosus : The Specificity of IRF5 to SLE.
The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, e...
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| Format: | Doctoral Thesis |
| Language: | English |
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Uppsala universitet, Institutionen för genetik och patologi
2007
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8332 http://nbn-resolving.de/urn:isbn:978-91-554-7038-8 |