Allosteric Regulation of mRNA Metabolism : -Mechanisms of Cap-Dependent Regulation of Poly(A)-specific Ribonuclease (PARN)

Allosteric Regulation of mRNA Metabolism : -Mechanisms of Cap-Dependent Regulation of Poly(A)-specific Ribonuclease (PARN)

Degradation of mRNA is a highly regulated step important for proper gene expression. Degradation of eukaryotic mRNA is initiated by shortening of the 3’ end located poly(A) tail. Poly(A)-specific ribonuclease (PARN) is an oligomeric enzyme that degrades the poly(A) tail with high processivity. A uni...

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Bibliographic Details
Main Author: Nilsson, Per
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för cell- och molekylärbiologi 2008
Subjects:
Cell and molecular biology
mRNA degradation
deadenylation
cap
poly(A)
PARN
allosteric regulation
Cell- och molekylärbiologi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8647
http://nbn-resolving.de/urn:isbn:978-91-554-7163-7

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8647
http://nbn-resolving.de/urn:isbn:978-91-554-7163-7

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