P38(MAPK) negatively regulates monoamine oxidase-A activity as well as its sensitivity to Ca2+
Monoamine oxidase (MAO) is a mitochondrial deaminating enzyme that exists as two isoforms, MAO-A and -B. The MAO-mediated reaction generates hydrogen peroxide (H2O2) as a normal by-product. Dysregulation of MAO has been implicated in a variety of neuropsychiatric and neurodegenerative disorders, as...
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| Format: | Others |
| Language: | en |
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University of Saskatchewan
2008
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| Online Access: | http://library.usask.ca/theses/available/etd-01032008-121637/ |