The Alzheimer disease-related presenilin-1(M146V) inhibits monoamine oxidase-A function in vivo and in vitro.
Presenilin-1 (PS-1) is the catalytic core of the ã-secretase complex, which is best known for its role in the generation of the Alzheimer disease (AD)-related â-amyloid peptide. Mutated forms of PS-1 are known to be associated with particularly aggressive forms of AD. Changes in monoaminergic neurot...
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| Format: | Others |
| Language: | en |
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University of Saskatchewan
2011
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| Online Access: | http://library.usask.ca/theses/available/etd-02032011-152045/ |