Therapeutic immunomodulation of allergic lung disease using regulatory dendritic cells in a mouse model of asthma

Therapeutic immunomodulation of allergic lung disease using regulatory dendritic cells in a mouse model of asthma

We report herein that IL-10-treated dendritic cells (DC) can be used effectively to reverse established severe asthma-like disease in a mouse model. Our lab had shown previously that allergen-presenting splenic CD8¦Á+ DCs could ¡Ö50% reduce airway hyper responsiveness (AHR), eosinophilia, and Th2 re...

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Bibliographic Details
Main Author: Nayyar, Aarti
Other Authors: Gordon, John R.
Format: Others
Language:en
Published: University of Saskatchewan 2009
Subjects:
Immunomodulation
Th2 responses
Airway Hyperresponsiveness
Asthma
Dendritic cells
regulatory T cells
Interleukin-10
Online Access:http://library.usask.ca/theses/available/etd-02072009-093757/

Internet

http://library.usask.ca/theses/available/etd-02072009-093757/

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