Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism

In order to investigate the structural features responsible for the cytotoxicity of the naturally occurring lignan nordihydroguaiaretic acid, the synthesis of four structural analogues of NDGA is proposed for the purpose of studying their oxidative metabolism. One analogue in particular (1), a mono-...

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Bibliographic Details
Main Author: Maloney, Katherine Ann
Other Authors: Berry, Mark
Format: Others
Language:en
Published: University of Saskatchewan 2010
Subjects:
Online Access:http://library.usask.ca/theses/available/etd-05192010-134624/