Dendritic cell based cancer vaccines using adenovirally mediated expression of the HER-2/neu gene and apoptotic tumor cells expressing heat shock protein 70

Dendritic cell based cancer vaccines using adenovirally mediated expression of the HER-2/neu gene and apoptotic tumor cells expressing heat shock protein 70

Human Epidermal Growth Factor Receptor 2 (HER-2/neu) is a breast tumor antigen (Ag) commonly overexpressed in 30% of breast cancer cases. Both HER-2/neu-targeted DNA-based and transgene modified dendritic cell (DC)-based vaccines are potent elements in eliciting HER-2/neu specific antitumor immune r...

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Bibliographic Details
Main Author: Chan, Tim
Other Authors: Saxena, Anurag
Format: Others
Language:en
Published: University of Saskatchewan 2006
Subjects:
replication deficient adenovirus
cancer vaccine
breast cancer
dendritic cell
HER-2/neu
apoptosis
Heat Shock Protein 70
Online Access:http://library.usask.ca/theses/available/etd-08232006-203717/

Internet

http://library.usask.ca/theses/available/etd-08232006-203717/

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