DNA damage tolerance in mammalian cells
DNA is susceptible to both exogenous and endogenous damaging agents. Damage is constantly reversed by a wide range of DNA repair pathways. Lesions which escape such repair may cause nucleotide mis-pairing and stalled replication, resulting in mutagenesis and cell death, respectively if left unresolv...
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| Format: | Others |
| Language: | en |
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University of Saskatchewan
2009
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| Online Access: | http://library.usask.ca/theses/available/etd-08262009-102011/ |