Quetiapine modulates anxiety-like behaviours and alleviates the decrease of BDNF in the amygdala of an APP/PS1 transgenic mouse model of Alzheimers disease

Quetiapine modulates anxiety-like behaviours and alleviates the decrease of BDNF in the amygdala of an APP/PS1 transgenic mouse model of Alzheimers disease

Quetiapine, an atypical antipsychotic drug, is effective in treating the behavioural and the psychological symptoms of dementia (BPSD). The objective of this study was to examine the effects of quetiapine on anxiety-like behaviour in the amyloid precursor protein (APP)/ presenilin 1 (PS1) double tra...

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Bibliographic Details
Main Author: Tempier, Adrien Paul
Other Authors: Li, Xin-Min
Format: Others
Language:en
Published: University of Saskatchewan 2009
Subjects:
Alzheimers disease
APP/PS1 transgenic mouse
Quetiapine
Anxiety
Amygdala
Brain derived neurotrophic factor
Memory
Hippocampus
Online Access:http://library.usask.ca/theses/available/etd-09122009-170948/

Internet

http://library.usask.ca/theses/available/etd-09122009-170948/

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