Genetic engineering of a fusion protein possessing anti-tumor Fv and tumor necrosis factor alpha
In order to target tumor necrosis factor alpha (TNF-α) specifically to tumor cells, we designed, constructed and expressed a recombinant fusion protein single-chain Fv/TNF-α (scFv/TNF-α) containing the scFv of B72.3 monoclonal antibody and the human TNF-α in 'Escherichia coli' using geneti...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
University of Saskatchewan
1999
|
| Online Access: | http://library.usask.ca/theses/available/etd-10212004-002517 |