The potential involvement of semicarbazide-sensitive amine oxidase-mediated reactions and aldehyde stress in the aggregation, cytotoxicity and clearance of beta-amyloid related to Alzheimer's disease
Beta-amyloid (Aâ) remains to be the focus of research interest of the pathogenesis of Alzheimers disease (AD). Aâ is subject to oligomerization and its polymers are cytotoxic. Advanced aggregation leads to formation of senile plaques. Depositions of Aâ surrounding the cerebral vasculature, i.e. cere...
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| Format: | Others |
| Language: | en |
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University of Saskatchewan
2010
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| Online Access: | http://library.usask.ca/theses/available/etd-12142009-170726/ |