Proteolytic Processing of the Amyloid Precursor Protein During Apoptosis and Cell Cycle: Implications for Alzheimer's Disease
Alzheimer's disease is characterized by the presence of amyloid plaques, made up primarily of Aϐ peptides, and neurofibrillary tangles, containing hyperphosphorylated tau. Aϐ is generated by sequential proteolysis of the amyloid precursor protein (APP) by beta and gamma secretases. The leading...
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| Format: | Others |
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Scholar Commons
2013
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| Online Access: | http://scholarcommons.usf.edu/etd/4486 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=5683&context=etd |