5-Aminolevulinate Synthase: Characterization of the Enzymatic Mechanism, Reaction Selectivity, and Structural Plasticity

5-Aminolevulinate Synthase: Characterization of the Enzymatic Mechanism, Reaction Selectivity, and Structural Plasticity

5-Aminolevulinate synthase (ALAS) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation between glycine and succinyl-CoA to generate coenzyme A (CoA), CO2, and 5-aminolevulinate (ALA). The chemical mechanism of this reaction, which represents the first and regulated step of heme bio...

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Bibliographic Details
Main Author: Stojanovski, Bosko M.
Format: Others
Published: Scholar Commons 2015
Subjects:
5-Aminolevulinate synthase
heme
pyridoxal 5’-phosphate
enzyme mechanisms
molten globule
Medicine and Health Sciences
Online Access:http://scholarcommons.usf.edu/etd/5879
http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7075&context=etd

Internet

http://scholarcommons.usf.edu/etd/5879
http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7075&context=etd

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