Therapeutic Modulation of Cancer Metabolism with Dichloroacetate and Metformin
The robust glycolytic metabolism of glioblastoma multiforme (GBM) has proven them susceptible to increases in oxidative metabolism induced by the pyruvate mimetic dichloroacetate (DCA). Recent reports demonstrate that the anti-diabetic drug metformin enhances the damaging oxidative stress associated...
| Main Author: | |
|---|---|
| Format: | Others |
| Published: |
Scholar Commons
2017
|
| Subjects: | |
| Online Access: | http://scholarcommons.usf.edu/etd/6778 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7975&context=etd |