Proteolysis of CX3CL1 Impacts CX3CR1 Signaling and Therapeutic Benefits in a Tauopathy Model

Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder and the most common form of dementia. The hallmark pathologies of AD are extracellular aggregates of amyloid-beta, intracellular aggregates of microtubule associated protein tau and increased neuroinflammation. Current therapeutic...

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Bibliographic Details
Main Author: Finneran, Dylan John
Format: Others
Published: Scholar Commons 2018
Subjects:
Online Access:https://scholarcommons.usf.edu/etd/7504
https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=8701&context=etd